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Published on: April 1, 2019
Pharmacogenomics Guided-Personalization of Warfarin and Tamoxifen
Theodore J Wigle1, Laura E Jansen2, Wendy A Teft3
1Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5A5, Canada. twigle@uwo.ca.
Abstract:
The use of pharmacogenomics to personalize drug therapy has been a long-sought goal for warfarin and tamoxifen. However, conflicting evidence has created reason for hesitation in recommending pharmacogenomics-guided care for both drugs. This review will provide a summary of the evidence to date on the association between cytochrome P450 enzymes and the clinical end points of warfarin and tamoxifen therapy. Further, highlighting the clinical experiences that we have gained over the past ten years of running a personalized medicine program, we will offer our perspectives on the utility and the limitations of pharmacogenomics-guided care for warfarin and tamoxifen therapy.
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