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Related Experiment Videos

Neuropsychological functioning in hemiparkinsonism.

L X Blonder1, R E Gur, R C Gur

  • 1Department of Psychiatry, University of Pennsylvania, Philadelphia 19104.

Brain and Cognition
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

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Early Parkinson's disease (PD) shows neuropsychological deficits lateralized with motor symptoms. Cognitive and motor impairments appear on the same side as the body's symptoms, even in early stages.

Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Psychology

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder primarily affecting motor function.
  • Cognitive impairments are common in PD, but their early lateralization is not well understood.
  • Understanding early cognitive changes can aid in diagnosis and management.

Purpose of the Study:

  • To investigate the pattern of neuropsychological deficits in early hemiparkinsonian patients.
  • To determine if cognitive impairments lateralize according to the side of motor symptoms.

Main Methods:

  • Administered a standardized neuropsychological battery to 21 hemiparkinsonian patients and 17 controls.
  • Assessed intellectual cognitive, memory, attention, language, abstraction, mental flexibility, and sensory-motor functions.

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  • Matched patients and controls for age and education.

    • Main Results:

    • Hemiparkinsonian patients showed impairments in all tested functions except sensory.
    • Motor function deficits were ipsilateral to the side of motor symptoms.
    • Right-sided motor symptoms correlated with verbal deficits; left-sided symptoms correlated with spatial deficits.

    Conclusions:

    • Neuropsychological deficits in early Parkinson's disease can be lateralized.
    • The pattern of cognitive deficits mirrors the lateralization of motor symptoms.
    • This lateralization may serve as an early indicator of Parkinson's disease progression.