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Menopausal asthma-much ado about nothing? An observational study.

Katarzyna Bialek-Gosk1, Marta Maskey-Warzechowska1, Rafal Krenke1

  • 1a Department of Internal Medicine , Pulmonary Diseases and Allergy, Medical University of Warsaw , Warsaw , Poland.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|December 15, 2017
PubMed
Summary

Menopausal asthma in Polish women shows a higher rate of irreversible airway obstruction. This study did not find distinct features to classify menopausal asthma as a separate phenotype.

Keywords:
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Area of Science:

  • Pulmonology
  • Women's Health
  • Endocrinology

Background:

  • Menopausal asthma is considered a distinct phenotype.
  • Hormonal changes during menopause may influence asthma characteristics.

Purpose of the Study:

  • To identify specific features of asthma in postmenopausal women.
  • To compare asthma characteristics between premenopausal and menopausal women.

Main Methods:

  • Compared asthma severity, control, pulmonary function, exhaled nitric oxide (FeNO), and sputum/blood cell counts in premenopausal, and two groups of menopausal women.
  • Enrolled 27 premenopausal women, 13 menopausal women with pre-existing asthma, and 16 menopausal women with new-onset asthma.

Main Results:

  • No significant differences in asthma severity, control, blood eosinophils, or FeNO were observed between groups.
  • Menopausal women exhibited a higher incidence of irreversible airway obstruction (56.2%-84.6%) compared to premenopausal women (22.2%).
  • Sputum eosinophilia was highest in menopausal women with pre-existing asthma, but this difference was not statistically significant.

Conclusions:

  • Menopausal asthma is associated with increased irreversible airway obstruction, irrespective of asthma duration.
  • Age may independently contribute to pulmonary function impairment in asthmatic women.
  • This study did not identify specific features to distinguish menopausal asthma as a unique phenotype.