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1School of Pharmacy, JBL Building, University of Lincoln, Green Lane, Lincoln, LN6 7DL, UK.
Future Medicinal Chemistry
|December 16, 2017
Summary
Dr. Ishwar Singh is developing novel antimicrobials using rational design to combat resistant bacteria. His research also focuses on bioconjugations, drug delivery, and diagnostics.
Area of Science:
- Organic Chemistry
- Biological Chemistry
- Medicinal Chemistry
Background:
- Senior Lecturer Ishwar Singh's expertise spans organic chemistry and bioconjugation techniques.
- He has held prestigious fellowships, including Alexander von Humboldt and DANIDA.
- His work involves modifications of DNA, RNA, and polymers.
Discussion:
- Current research focuses on rational design of novel antimicrobials against highly resistant bacteria.
- Targeted resistant bacteria include methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, mycobacteria, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa.
- The research also explores biologics delivery, peptides, and sequence-selective DNA cross-linking.
Key Insights:
- Development of bioconjugations for DNA, RNA, and polymer modifications.
- Rational design approach for novel antimicrobial agents.
- Application of nanoparticles for advanced drug delivery and diagnostics.
Outlook:
- Potential for new therapeutic strategies against antibiotic-resistant infections.
- Advancements in targeted drug delivery systems.
- Innovations in diagnostic tools utilizing modified nanoparticles.
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