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Vaccines for the Prevention of Melioidosis and Glanders

Monica M Johnson1, Kristy M Ainslie1

  • 1Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, USA.

Current Tropical Medicine Reports
|December 16, 2017
PubMed
Abstract

Insights

Developing vaccines against Burkholderia pseudomallei and Burkholderia mallei is critical due to their high infectivity and potential biowarfare use. Current pre-clinical vaccine research shows limited long-term survival after lethal challenges in animal studies.

Area of Science:

  • Microbiology
  • Vaccinology
  • Infectious Diseases

Background:

  • Burkholderia pseudomallei and Burkholderia mallei are highly infectious bacteria with limited treatment options.
  • These pathogens pose a significant threat due to their potential use as biological warfare agents.
  • Current vaccine development for these bacteria is in the pre-clinical stages, with no market-approved formulations.

Purpose of the Study:

  • To review current vaccine strategies against Burkholderia pseudomallei and Burkholderia mallei.
  • To provide insights for the development of successful vaccines against these pathogens.

Main Methods:

  • Review of pre-clinical vaccine research for B. pseudomallei and B. mallei.
  • Evaluation of live attenuated and subunit vaccine formulations in animal models.

Main Results:

  • Several live attenuated and subunit vaccine formulations have been tested in animal studies.
  • No reported significant long-term survival after lethal challenge in evaluated studies.

Conclusions:

  • Effective vaccines against B. pseudomallei and B. mallei are urgently needed.
  • Current vaccine strategies require further development to ensure long-term survival after infection.
  • This review highlights the most current strategies and offers insights for future vaccine development.
Keywords:
Burkholderia malleiBurkholderia pseudomalleiglandersmelioidosisvaccines

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