Can Probability Maps of Swept-Source Optical Coherence Tomography Predict Visual Field Changes in Preperimetric...

Area of Science:

• Ophthalmology
• Medical Imaging
• Glaucoma Research

Background:

• Preperimetric glaucoma (PPG) presents a diagnostic challenge due to subclinical visual field (VF) damage.
• Early detection and prediction of VF loss are crucial for timely intervention in glaucoma management.

Purpose of the Study:

• To assess the utility of swept-source optical coherence tomography (SS-OCT) probability maps for detecting existing VF sensitivity reductions.
• To evaluate the predictive capability of SS-OCT probability maps for future VF changes in PPG patients.

Main Methods:

• A longitudinal study analyzed 43 eyes of 43 PPG patients over at least 2 years.
• Wide-field SS-OCT scanning and standard automated perimetry (SAP) were performed.
• SS-OCT probability maps were generated and overlapped with SAP VF test points to identify vulnerable areas.

Main Results:

• Significant baseline VF reduction was detected in 44.2% of eyes within areas of structural change identified by SS-OCT probability maps.
• Subsequent VF changes were observed in 37.2% of eyes within corresponding SS-OCT probability map changes during follow-up.
• Vulnerable VF points typically appeared in superior and inferior arcuate patterns.

Conclusions:

• SS-OCT probability maps demonstrate significant potential in detecting current VF deficits in PPG.
• These maps can predict future VF deterioration, aiding in the monitoring of PPG progression.
• Integrating SS-OCT probability maps with SAP results offers a valuable tool for clinical diagnosis and management of PPG.