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Finding the needle in the haystack: systematic identification of psychobiotics
Aisling Bambury1,2, Kiran Sandhu1, John F Cryan1,3
1APC Microbiome Institute, University College Cork, Cork, Ireland.
British Journal of Pharmacology
|December 16, 2017
Summary
Psychobiotics, live bacteria conferring mental health benefits, show promise for treating psychiatric disorders like anxiety and depression. This review outlines their characteristics to guide the identification of future clinical psychobiotic therapies.
Area of Science:
- Neuroscience
- Microbiology
- Psychiatry
Background:
- The brain-gut-microbiota axis is a key area in neuroscience.
- Psychobiotics are live bacteria that offer mental health benefits.
- Preclinical studies show psychobiotics' potential for psychiatric disorders.
Purpose of the Study:
- To explore the characteristics of psychobiotics.
- To provide a framework for identifying novel psychobiotic candidates.
- To advance the development of psychobiotic therapies for mental health.
Main Methods:
- Literature review of psychobiotic research.
- Analysis of microbial characteristics relevant to mental health.
- Discussion of potential psychobiotic applications in clinical settings.
Main Results:
- Psychobiotics demonstrate potential in preclinical models of stress, anxiety, and depression.
- Specific microbial characteristics are crucial for psychobiotic efficacy.
- Further research is needed to translate findings to clinical practice.
Conclusions:
- Psychobiotics represent a promising therapeutic avenue for psychiatric illnesses.
- Identifying optimal psychobiotic strains requires understanding their unique properties.
- The brain-gut-microbiota axis offers novel targets for mental health treatment.
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