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Our Gut Microbiome: The Evolving Inner Self.

Parag Kundu1, Eran Blacher2, Eran Elinav2

  • 1Singapore Centre for Environmental Life Sciences Engineering, 60 Nanyang Drive, Singapore 637551, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.

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|December 16, 2017
PubMed
Summary
This summary is machine-generated.

The holobiont concept redefines individuality by integrating host and microbial contributions across the human lifespan. Understanding these symbiotic relationships is key to personalized characteristics and human evolution.

Keywords:
Microbiomeaginglifespannervous systemneurodegenerative disorders

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Area of Science:

  • Human biology
  • Microbiome research
  • Evolutionary science

Background:

  • The holobiont concept integrates host and microbial communities, offering a new perspective on individuality.
  • Human evolution and personalized characteristics are influenced by complex microbial-host associations.

Purpose of the Study:

  • To explore the evolving microbial-host associations throughout the human lifespan.
  • To discuss the biological symbiosis between the microbiome and its host.
  • To highlight challenges in understanding these interactions and their physiological impacts.

Main Methods:

  • Review of current knowledge on microbiome-host symbiosis.
  • Analysis of distinct developmental milestones in human life.
  • Exploration of microbiome-nervous system interactions.

Main Results:

  • Snapshots of evolving microbial-host associations across the human lifespan are presented.
  • The study discusses the biological symbiosis and its implications.
  • Challenges in understanding microbiome-host interactions are identified.

Conclusions:

  • The holobiont concept provides a comprehensive view of human individuality and evolution.
  • Microbiome-host interactions, including the microbiome-nervous system axis, are crucial for human variation.
  • Further research is needed to fully understand these complex symbiotic relationships.