Infection related to deep brain stimulation in patients with Parkinson disease: Clinical characteristics and risk

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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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Mi Sun Kim1, Jae Sim Jeong2, Ho-Sung Ryu1

  • 1Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Journal of the Neurological Sciences
|December 17, 2017
PubMed
Abstract

Insights

Short prophylactic antibiotic therapy and intensive care unit (ICU) management after deep brain stimulation (DBS) surgery may increase infection risk in Parkinson disease (PD) patients.

Area of Science:

  • Neurosurgery
  • Infectious Disease
  • Neurology

Background:

  • Deep brain stimulation (DBS) is a treatment for Parkinson disease (PD).
  • Infection is a complication of DBS surgery.
  • Risk factors for DBS infection in PD patients remain debated.

Purpose of the Study:

  • To investigate clinical characteristics and risk factors for infection following DBS surgery in PD patients.
  • To identify modifiable factors influencing post-DBS infection rates.

Main Methods:

  • Retrospective analysis of 246 DBS surgeries in 169 advanced PD patients.
  • Multivariate logistic regression to identify risk factors for infection.
  • Data collected on clinical characteristics and outcomes.

Main Results:

  • Infection occurred in 5% of surgeries and 7% of patients.
  • Most infections (75%) occurred within 3 months.
  • Short prophylactic antibiotic duration (OR=0.62) and ICU management (OR=5.43) were associated with increased infection risk.

Conclusions:

  • Short prophylactic antibiotic therapy may be insufficient for preventing DBS infections in PD.
  • Intensive care unit (ICU) management immediately post-surgery is a significant risk factor for infection.
  • Optimizing antibiotic protocols and post-operative care may reduce DBS-related infections in PD.
Keywords:
Deep brain stimulationInfectionParkinson diseaseRisk factors

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