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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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Noncoding RNAs: Master Regulators of Inflammatory Signaling.

Chen Li Chew1, Stephanie Ana Conos1, Bilal Unal2

  • 1Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore; These authors contributed equally.

Trends in Molecular Medicine
|December 17, 2017
PubMed
Summary
This summary is machine-generated.

Noncoding RNAs (ncRNAs) are emerging as key regulators of inflammatory signaling, moving beyond their previous perception as mere transcriptional noise. This review highlights their newly discovered functions and therapeutic potential in inflammatory diseases.

Keywords:
ERK/MAPK pathwayNF-κB signalinginflammationlncRNAncRNA

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Area of Science:

  • Molecular Biology
  • Immunology
  • Genetics

Background:

  • Inflammatory signaling is implicated in numerous diseases, including arthritis and cancer.
  • The role of noncoding RNAs (ncRNAs) in inflammation has been historically underappreciated.
  • ncRNAs are now recognized as critical regulators of cellular signaling pathways.

Purpose of the Study:

  • To review the newly discovered mechanisms and functions of ncRNAs in regulating inflammatory signaling.
  • To discuss advances in experimental techniques enabling research in this area.
  • To explore the therapeutic potential of ncRNAs for inflammatory diseases.

Main Methods:

  • Literature review of recent studies on ncRNAs and inflammation.
  • Analysis of emerging experimental techniques for studying ncRNA function.
  • Synthesis of current understanding of ncRNA-mediated inflammatory regulation.

Main Results:

  • ncRNAs play significant roles in controlling inflammatory signaling pathways.
  • Novel mechanisms of ncRNA regulation in inflammation have been identified.
  • Advances in technology are facilitating rapid progress in this research field.

Conclusions:

  • ncRNAs are crucial players in the intricate network of inflammatory signaling.
  • Targeting ncRNAs offers promising new therapeutic strategies for inflammatory conditions.
  • Future clinical applications of ncRNA-based therapies for inflammatory diseases are anticipated.