Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Depression01:03

Long-term Depression

3.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.4K
Long-term Depression01:05

Long-term Depression

33.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K
Neuroplasticity01:01

Neuroplasticity

1.9K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
1.9K
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

932
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
932
Aging01:26

Aging

849
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
849
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

242
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
242

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ubiquitin-Proteasome-Mediated Protein Degradation and Disorders of the Central Nervous System.

International journal of molecular sciences·2025
Same author

Attenuated Tissue Damage With Mechanical Tissue Resuscitation in a Pig Model of Spinal Cord Injury.

Journal of neurotrauma·2023
Same author

Novel treatment of intracerebral hemorrhage with mechanical tissue resuscitation.

Journal of neurosurgery·2023
Same author

The Proteasome and Ageing.

Sub-cellular biochemistry·2023
Same author

Degradation of Transcriptional Repressor ATF4 during Long-Term Synaptic Plasticity.

International journal of molecular sciences·2020
Same author

Perturbations of Ubiquitin-Proteasome-Mediated Proteolysis in Aging and Alzheimer's Disease.

Frontiers in aging neuroscience·2019

Related Experiment Video

Updated: Feb 16, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

95.3K

Age-dependent changes in brain hydration and synaptic plasticity.

Anirudh Vashisht1, Michael Morykwas1, Ashok N Hegde1

  • 1Plastic and Reconstructive Surgery Research, Wake-Forest University School of Medicine, Winston-Salem, NC, United States.

Brain Research
|December 17, 2017
PubMed
Summary
This summary is machine-generated.

Aging causes brain dehydration, impacting synaptic plasticity and potentially cognitive function. This study shows progressive brain water loss in mice, affecting neuronal responses and long-term potentiation.

Keywords:
AgingHippocampal excitabilityHydration

More Related Videos

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.5K
Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

6.7K

Related Experiment Videos

Last Updated: Feb 16, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
14:57

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Published on: March 23, 2011

95.3K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.5K
Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

6.7K

Area of Science:

  • Neuroscience
  • Aging Research
  • Physiology

Background:

  • Cognitive function declines with age, but underlying causes and individual differences are not fully understood.
  • Hydration levels decrease with aging, yet its role in age-related cognitive dysfunction remains unknown.
  • Brain dehydration is a potential factor in age-associated cognitive changes.

Purpose of the Study:

  • To investigate the relationship between aging, brain dehydration, and synaptic plasticity in mice.
  • To determine if age-related dehydration impacts neuronal function and long-term potentiation.

Main Methods:

  • Colloidosmotic-pressure titration was used to measure brain hydration in aging mice.
  • Hippocampal slices from young mice were experimentally dehydrated to levels observed in aged mice.
  • Basal synaptic responses and long-term potentiation (LTP) were assessed in vitro.

Main Results:

  • Progressive brain dehydration was observed in aging mice, with a significant loss of brain water by 40 weeks.
  • Experimental dehydration in young mouse hippocampal slices amplified basal synaptic responses.
  • The induction of late-phase long-term potentiation was impaired under dehydrated conditions.

Conclusions:

  • Aging in mice is associated with progressive brain dehydration.
  • Age-related brain dehydration dysregulates in vitro synaptic plasticity.
  • Dehydration may contribute to age-related changes in synaptic plasticity and neuronal function.