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Related Experiment Videos

Can hydration forces induce lateral phase separations in lamellar phases?

G Bryant1, J Wolfe

  • 1School of Physics, University of New South Wales, Kensington, Australia.

European Biophysics Journal : EBJ
|January 1, 1989
PubMed
Summary

Repulsive forces in lipid membranes at low hydration are due to hydration interactions. A model predicts phase separation in mixed lipid systems, impacting dehydrated biological cells.

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Area of Science:

  • Biophysics
  • Membrane Biophysics
  • Lipid Bilayer Dynamics

Background:

  • Repulsive forces between lipid membranes at low hydration are significant.
  • These forces are attributed to hydration interactions that differ across lipid species.
  • Understanding these interactions is crucial for membrane behavior.

Purpose of the Study:

  • To incorporate hydration interactions into a model of lamellar lipid phases.
  • To investigate phase separation in mixtures of two membrane components (lipids or lipid-protein).
  • To assess the implications for biological cells under dehydration stress.

Main Methods:

  • Developed a model for lamellar phases with two membrane components.
  • Included hydration interactions, varying by lipid species.

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  • Modeled surface polarization as a linear combination of component polarizations.

    • Main Results:

    • The model predicts phase separation in lipid mixtures at low hydration levels.
    • Hydration interactions were successfully integrated into the lamellar phase model.
    • The study highlights the role of lipid species in governing interactions.

    Conclusions:

    • Phase separation in lipid membranes at low hydration is a predictable outcome of hydration interactions.
    • These findings have potential implications for cellular dehydration, such as during freezing or desiccation.
    • The model provides a framework for understanding membrane behavior in response to hydration changes.