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Published on: September 6, 2024
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DRD3 Ser9Gly Polymorphism and Its Influence on Risperidone Response in Autistic Children
Negar Firouzabadi1, Anna Nazariat, Kamiar Zomorrodian
1Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Summary
Genetic variations in the dopamine receptor D2 gene (DRD3) may predict autism treatment response. The Gly allele (rs6280) showed significantly better outcomes with risperidone in children with autism.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Autism is a complex neuropsychiatric disorder with unclear causes, though genetics plays a significant role.
- Pharmacogenetics offers potential for improved symptom management in autism.
- Risperidone is a commonly used antipsychotic for managing autism symptoms.
Purpose of the Study:
- To investigate the association between the dopamine receptor D2 (DRD3) Ser9Gly (rs6280) genetic variant and the clinical response to risperidone in children with autism.
- To explore the role of dopaminergic system genetics in autism treatment.
Main Methods:
- Fifty-six Persian children diagnosed with autism (age 2.5-14 years) were included.
- Autism diagnosis and severity were assessed using DSM-V criteria and ABC-C checklists.
- Response to 8 weeks of risperidone treatment was evaluated, and DRD3 Ser9Gly (rs6280) genotypes were determined using PCR-RFLP.
Main Results:
- Individuals carrying the Gly allele or Gly/Gly and Ser/Gly genotypes showed a significantly better response to risperidone.
- Compared to Ser/Ser genotype carriers, Gly allele carriers had a 4.18-fold increased likelihood of responding to risperidone (P=0.027).
- Ser/Gly genotype carriers had a 6.825-fold increased likelihood of responding to risperidone (P=0.014).
Conclusions:
- Genetic variations in the DRD3 gene may influence the clinical effectiveness of risperidone in individuals with autism.
- These findings support the role of pharmacogenetics in personalizing autism treatment.
- Further research is warranted to explore DRD3's role in antipsychotic response in autism.
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