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Updated: Feb 16, 2026
11:34
A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
Published on: April 11, 2025
865
Update on Dendritic Cell-Induced Immunological and Clinical Tolerance
Carolina Obregon1, Rajesh Kumar1, Manuel Antonio Pascual1,2
1Department of Medicine, Transplantation Centre and Transplantation Immunopathology Laboratory, Service of Immunology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
Frontiers in Immunology
|December 19, 2017
Summary
Tolerogenic dendritic cells (tolDCs) show promise for treating autoimmune diseases and preventing organ transplant rejection. Further research is needed to optimize tolDC therapies for in vivo use.
Area of Science:
- Immunology
- Cell Biology
- Therapeutics
Background:
- Dendritic cells (DCs) are crucial antigen-presenting cells bridging innate and adaptive immunity.
- DCs play key roles in immune responses, immune tolerance, and maintaining tissue homeostasis.
- Specialized DC subsets are involved in initiating immune responses and regulating immune tolerance.
Purpose of the Study:
- To review the characteristics and classification of human DCs.
- To discuss the role of DCs in immune regulation.
- To explore the potential of tolerogenic DCs (tolDCs) for therapeutic applications in autoimmune diseases and organ transplantation.
Main Methods:
- Review of current literature on dendritic cell subsets and their functions.
- Analysis of in vitro and in vivo manipulation strategies for DCs.
- Focus on the application of tolDCs in preclinical and clinical studies.
Main Results:
- DCs are central to immune regulation and tolerance induction.
- Tolerogenic DCs (tolDCs) are being investigated for therapeutic potential.
- Ongoing clinical trials show promise for tolDC-based therapies.
Conclusions:
- Dendritic cells are key players in immune regulation and tolerance.
- Tolerogenic DCs offer a promising therapeutic avenue for autoimmune diseases and transplant rejection.
- Further research is essential to optimize tolDC-based treatments for in vivo application.
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