Next generation sequencing: clinical applications in solid tumours

Area of Science:

• Oncology
• Genomics
• Molecular Diagnostics

Background:

• Next generation sequencing (NGS) has elucidated genetic alterations driving cancer pathogenesis.
• NGS is increasingly adopted in routine clinical diagnostics for malignant tumors.

Purpose of the Study:

• To highlight the central role of NGS in modern cancer care.
• To underscore the utility of NGS in diagnosis, targeted therapy selection, resistance mechanism identification, and disease monitoring.

Main Methods:

• Review of current applications of NGS in clinical oncology.
• Analysis of NGS's impact on personalized cancer medicine.

Main Results:

• NGS provides critical insights into tumor molecular profiles.
• NGS facilitates the identification of actionable therapeutic targets.
• NGS aids in understanding and overcoming treatment resistance.

Conclusions:

• NGS is integral to implementing molecularly adapted cancer therapies.
• The integration of NGS enhances precision oncology and patient management.