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Updated: Feb 16, 2026

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

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Next generation sequencing: clinical applications in solid tumours

Leonhard Müllauer1

  • 1Department of Pathology, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

Memo
|December 19, 2017
PubMed

Insights

Next generation sequencing (NGS) is revolutionizing cancer diagnostics and treatment. This technology identifies genetic alterations for personalized cancer therapies and disease monitoring.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Diagnostics

Background:

  • Next generation sequencing (NGS) has elucidated genetic alterations driving cancer pathogenesis.
  • NGS is increasingly adopted in routine clinical diagnostics for malignant tumors.

Purpose of the Study:

  • To highlight the central role of NGS in modern cancer care.
  • To underscore the utility of NGS in diagnosis, targeted therapy selection, resistance mechanism identification, and disease monitoring.

Main Methods:

  • Review of current applications of NGS in clinical oncology.
  • Analysis of NGS's impact on personalized cancer medicine.

Main Results:

  • NGS provides critical insights into tumor molecular profiles.
  • NGS facilitates the identification of actionable therapeutic targets.
  • NGS aids in understanding and overcoming treatment resistance.

Conclusions:

  • NGS is integral to implementing molecularly adapted cancer therapies.
  • The integration of NGS enhances precision oncology and patient management.
Keywords:
Liquid biopsyMolecular pathologyNext generation sequencingPersonalized medicineTumor genetics

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