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Updated: Feb 16, 2026

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
Published on: January 15, 2015
Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for
Mingyang Hei1,2, Jun Wang1, Kelly Wang3
1Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
Abstract:
We synthesized a new type of upper critical solution temperature (UCST) thermally responsive polymers (TRPs) with varying responsive temperatures (cloud points). We then grafted one of the TRPs with a cloud point of 42°C on the surface of mesoporous silica nanoparticles (MSN) using disulfide bonds to achieve a novel, dual responsive release system. With this system, the cargo release profiles are responsive to both temperature and reducing agents. When loaded with doxorubicin hydrochloride (DOX), the system could deliver DOX into breast cancer cells (SK-BR-3) in a controlled fashion and present high toxicity.
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