Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis
Pavel Mikulecky1, Elena Andreeva1, Patricia Amara1
1Univ. Grenoble Alpes, CNRS, CEA, IBS, Grenoble, France.
FEBS Letters
|December 19, 2017
Abstract:
Viperin is a radical SAM enzyme that possesses antiviral properties against a broad range of enveloped viruses. Here, we describe the activity of human viperin with two molecules of the mevalonate pathway, geranyl pyrophosphate, and farnesyl pyrophosphate, involved in cholesterol biosynthesis. We postulate that the radical modification of these two molecules by viperin might lead to defects in cholesterol synthesis, thereby affecting the composition of lipid rafts and subsequent enveloped virus budding.
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