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Effect of beta-cypermethrin exposure on embryo implantation in mice
Yong-Jiang Zhou1, Ji-Hong Wang2, Li-Qing Wang1
1Maternal, Child and Adolescent Health, School of Public Health, Hainan Medical College, No.3 Yixueyuan Road, Longhua District, Hainan Province, 571199, PR China.
Abstract:
The aim of this study was to investigate the effect of β-CP on embryo implantation in mice. Forty female mice were randomly assigned to four groups of 10 mice each: one control group and three β-CP treated groups. The control group was administered corn oil only, while the three β-CP-treated groups were given corn oil containing 5, 10, and 20 mg/kg bw d β-CP for 3 months through intragastric administration. The results indicated that the administration of β-CP decreased the rate of embryo implantation (all p < 0.05), E2 level in the serum, and the expression of Homeobox A10 (HoxA10) protein. In addition, β-CP significantly increased ERa and PRA protein expression levels. These results suggest that β-CP can disrupt the balance of E2 and P, influence ERa and PRA expression and their downstream-related molecule Hoxa10, and decrease embryo implantation.
