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Multi-Modal Signals for Analyzing Pain Responses to Thermal and Electrical Stimuli

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Abnormal pain perception in patients with Multiple System Atrophy.

F Ory-Magne¹, J Pellaprat², E Harroch³

¹Department of Neurology, University Hospital of Toulouse, Toulouse, France; INSERM, Imagerie Cérébrale et Handicaps Neurologiques, UMR 1214, Toulouse, France; Clinical Investigation Center 1436, Inserm and University of Hospital of Toulouse, Toulouse, France; French Reference Center for Multiple System Atrophy, France; Toulouse Parkinson Expert Center, Toulouse University Hospital, Toulouse, France; NeuroToul Centre of Excellence in Neurodegeneration (COEN), France.

Parkinsonism & Related Disorders

|December 20, 2017

Summary

Multiple System Atrophy patients experience increased pain sensitivity compared to Parkinson's disease patients and healthy individuals. Levodopa (l-DOPA) did not significantly alter pain thresholds but may worsen pain tolerance in MSA patients.

Keywords:

Multi system atrophy Pain processing Pain thresholds Pain tolerance Parkinson's disease

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Area of Science:

Neurology
Pain Medicine
Neuroscience

Background:

Parkinson's disease (PD) and Multiple System Atrophy (MSA) are neurodegenerative disorders often accompanied by painful sensations.
Previous research on pain mechanisms in MSA has yielded inconsistent findings, necessitating further investigation.

Purpose of the Study:

To compare pain thresholds and tolerance between patients with MSA, PD, and healthy controls.
To evaluate the impact of levodopa (l-DOPA) on pain perception in MSA and PD patients.

Main Methods:

Assessment of subjective and objective pain thresholds using thermotest and RIII reflex.
Evaluation of pain tolerance, clinical pain, motor function, and psychological status in both OFF and ON l-DOPA states.

Main Results:

A higher prevalence of pain was reported in MSA (78.6%) compared to PD (37.5%).
MSA patients exhibited significantly lower subjective and objective pain thresholds than healthy controls and PD patients in the OFF state.
No significant differences in pain tolerance were observed across groups, and l-DOPA had similar effects on pain thresholds for MSA and PD patients.

Conclusions:

Patients with MSA demonstrate heightened pain perception relative to PD patients and healthy controls.
While l-DOPA did not significantly affect pain thresholds in MSA and PD, it showed a trend towards worsening pain tolerance in MSA patients.