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Related Experiment Video

Updated: Feb 16, 2026

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
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Lesion network localization of criminal behavior.

R Ryan Darby1,2,3,4,5, Andreas Horn2,3,6, Fiery Cushman7

  • 1Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37232; darby.ryan@gmail.com foxmdphd@gmail.com.

Proceedings of the National Academy of Sciences of the United States of America
|December 20, 2017
PubMed
Summary

Brain lesions can lead to criminal behavior. Mapping these lesions revealed a unique network of connected brain regions associated with criminality, distinct from other neuropsychiatric conditions.

Keywords:
criminalityfunctional connectivitylesionmoralitysociopathy

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Area of Science:

  • Neuroscience
  • Neurobiology of Crime
  • Brain Lesion Studies

Background:

  • Previously normal individuals can exhibit criminal behavior after brain lesions.
  • These rare cases offer insights into the neurobiological underpinnings of criminality.

Purpose of the Study:

  • To systematically map lesion locations associated with criminal behavior.
  • To identify the specific brain network connected to these lesions using lesion network mapping.

Main Methods:

  • Systematic mapping of 17 lesion cases with a temporal link to criminal behavior.
  • Utilized lesion network mapping to identify functionally connected brain regions.
  • Replicated findings in a separate cohort of 23 cases.

Main Results:

  • Lesion sites were heterogeneous, including prefrontal and temporal lobes, with no single region consistently damaged.
  • All identified lesions connected to a unique resting-state brain network.
  • This network implicated regions involved in morality, decision-making, and theory of mind, excluding cognitive control and empathy areas.

Conclusions:

  • Criminal behavior following brain lesions localizes to a distinct functional network, not a single brain region.
  • This network is unique compared to those associated with other neuropsychiatric syndromes.
  • Findings provide crucial insights into the neurobiology of criminal behavior.