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9,11-cyclic acetal derivatives of (9S)-9-dihydroerythromycin A
E Hunt1, D J Knowles, C Shillingford
1Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Betchworth, Surrey, UK.
The Journal of Antibiotics
|February 1, 1989
Abstract:
A series of 9,11-cyclic acetal derivatives of (9S)-9-dihydroerythromycin A (4) have been prepared and their antibacterial activities compared to those of erythromycin A and 9-dihydroerythromycin A. Many of the cyclic acetal derivatives showed better antibacterial activity than their parent 4. In particular, the acetaldehyde acetal (9-O,11-O-ethylidene-9-dihydroerythromycin A) (8b) showed good antibacterial activity in comparison with erythromycin A but was not sufficiently improved in vivo to warrant progression.