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Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease
Published on: February 8, 2022
Computed tomography of cardiomyopathies
Kevin Kalisz1, Prabhakar Rajiah2
1University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Insights
Cardiac computed tomography (CT) offers valuable insights into cardiomyopathies, especially for patients with MRI contraindications. Advanced CT technology aids in assessing coronary arteries, cardiac function, and treatment effectiveness.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Cardiology
Background:
- Cardiac computed tomography (CT) is crucial for evaluating cardiomyopathies.
- It is particularly useful for patients unable to undergo magnetic resonance imaging (MRI) due to contraindications like pacemakers or metallic device artifacts.
Purpose of the Study:
- To review the imaging techniques and specific applications of CT in the assessment of cardiomyopathies.
- To highlight CT's role in overcoming limitations of other non-invasive imaging modalities.
Main Methods:
- Review of current literature and technological advancements in cardiac CT.
- Discussion of CT's capabilities including high spatial and temporal resolution, wide field of view, and multi-planar reconstruction.
Main Results:
- CT enables detailed evaluation of coronary arteries in cardiomyopathies.
- It aids in characterizing cardiomyopathy phenotypes and quantifying cardiac volumes and function.
- CT is valuable for treatment planning and post-treatment assessment.
Conclusions:
- Cardiac CT is an increasingly important non-invasive tool for diagnosing and managing cardiomyopathies.
- Its advanced capabilities and utility in specific patient groups make it indispensable in cardiovascular imaging.
Abstract:
Cardiac computed tomography (CT) is increasingly used in the evaluation of cardiomyopathies, particularly in patients who are not able to undergo other non-invasive imaging tests such as magnetic resonance imaging (MRI) due to the presence of MRI-incompatible pacemakers/defibrillators or other contraindications or due to extensive artifacts from indwelling metallic devices. Advances in scanner technology enable acquisition of CT images with high spatial resolution, good temporal resolution, wide field of view and multi-planar reconstruction capabilities. CT is useful in cardiomyopathies in several ways, particularly in the evaluation of coronary arteries, characterization of cardiomyopathy phenotype, quantification of cardiac volumes and function, treatment-planning, and post-treatment evaluation. In this article, we review the imaging techniques and specific applications of CT in the evaluation of cardiomyopathies.
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