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Epidermal growth factor receptor: Role in human cancer

Prashanth Rajaram1, Poornima Chandra2, Smriti Ticku1

  • 1Department of Oral and Maxillofacial Surgery, V. S. Dental College and Hospital, Bangalore, Karnataka, India.

Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
|December 20, 2017
PubMed

Insights

Epidermal growth factor receptor (EGFR) signaling regulates cell growth and survival. Dysregulation of EGFR is implicated in cancer, making it a target for cancer therapies.

Area of Science:

  • Cell biology
  • Molecular oncology
  • Biochemistry

Background:

  • Cellular processes like growth and survival are regulated by external stimuli.
  • Signal transduction relies on cell surface or transmembrane receptors.
  • Epidermal growth factor receptor (EGFR) is a key type I receptor tyrosine kinase involved in cellular signaling.

Purpose of the Study:

  • To review the structural and physiological aspects of EGFR and its ligands.
  • To elucidate the role of EGFR in cancer development and progression.
  • To discuss EGFR-targeted therapeutic strategies.

Main Methods:

  • Literature review of existing research on EGFR.
  • Analysis of EGFR's role in cellular pathways.
  • Examination of EGFR's involvement in cancer pathogenesis.

Main Results:

  • EGFR and its ligands regulate multiple critical cellular pathways.
  • EGFR signaling is extensively studied for its biological and pathophysiological significance.
  • Evidence strongly links EGFR to the pathogenesis and progression of various cancers.

Conclusions:

  • EGFR plays a significant role in cellular regulation.
  • EGFR is a crucial factor in cancer development.
  • Targeting EGFR offers a promising therapeutic avenue for cancer treatment.

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