Related Experiment Video
Updated: Feb 16, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
Sources of Variation in Anesthetic Drug Costs
Jonathan P Wanderer1,2, Sara E Nelson1, Douglas L Hester1
1From the Department of Anesthesiology, Vanderbilt University, The Vanderbilt Clinic, Nashville, Tennessee.
Anesthesiologist and procedure type significantly impact anesthetic drug costs, but overall drug expenses are low. Cost-saving efforts may be more effective when focused on factors beyond individual provider practices.
Area of Science:
- Health Economics
- Anesthesiology
- Healthcare Management
Background:
- Healthcare expenditures, particularly anesthetic-related drug costs, are under increasing scrutiny.
- Identifying key drivers of variation in anesthetic drug spending is crucial for cost management.
Purpose of the Study:
- To identify significant contributors to anesthetic drug cost variation across different surgical procedures and institutions.
- To analyze the impact of attending anesthesiologist, case type, and procedure duration on drug costs.
Main Methods:
- Utilized anesthesia information management systems to collect volatile and intravenous drug costs for 8 inpatient surgical procedure types.
- Employed fixed-effects linear regression models with logarithmically transformed case cost as the outcome variable.
- Analyzed patient demographics, American Society of Anesthesiologists (ASA) physical status, case duration, provider, and institution as independent variables.
Main Results:
- The median anesthetic drug cost was $38.45, with models explaining 32.3%–35.2% of cost variation.
- Attending anesthesiologist, case type, and procedure duration were identified as the largest sources of cost variation.
- Average cost differences between attending anesthesiologists ranged from -$41.25 to +$95.67; institutional differences were minor ($5.73).
Conclusions:
- A significant portion of anesthetic drug cost variation remains unexplained, suggesting high per-case random variation.
- While attending anesthesiologist, procedure type, and case duration are key cost drivers, the overall anesthetic drug cost is relatively small.
- Cost-saving interventions focused on attending anesthesiologist practices may yield negligible savings; efforts might be better directed elsewhere.
Related Concept Videos
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Dosage Regimen: Individualization
Parenteral Anesthetics: Overview
Inhalational Anesthetics: Overview
Local Anesthetics: Common Agents and Their Applications
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...

