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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

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Major Challenges and Potential Microenvironment-Targeted Therapies in Glioblastoma

Ali S Arbab1, Mohammad H Rashid2, Kartik Angara3

  • 1Tumor Angiogenesis laboratory, Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Augusta University, Augusta, GA 30912, USA. aarbab@augusta.edu.

International Journal of Molecular Sciences
|December 21, 2017
PubMed

Insights

Glioblastoma (GBM) treatment faces challenges due to therapy resistance. Targeting the tumor microenvironment (TME) may overcome resistance mediated by myeloid cells, improving GBM outcomes.

Area of Science:

  • Neuro-oncology
  • Cancer immunology
  • Tumor microenvironment research

Background:

  • Glioblastoma (GBM) is a highly malignant, heterogeneous, and therapy-resistant brain tumor.
  • Current treatments include surgery, chemotherapy, and radiotherapy, with limited success.
  • Adjuvant therapies like antiangiogenic treatments (AATs) can paradoxically increase myeloid cell infiltration, leading to resistance and relapse.

Purpose of the Study:

  • To review clinical and preclinical findings on Glioblastoma (GBM) challenges.
  • To discuss strategies for overcoming therapy resistance mediated by myeloid cells within the tumor microenvironment (TME).
  • To explore potential combination therapies for improved GBM treatment.

Main Methods:

  • Comprehensive review of existing clinical and preclinical literature on Glioblastoma (GBM).
  • Analysis of mechanisms underlying myeloid cell-mediated therapy resistance.
  • Identification of potential therapeutic targets within the tumor microenvironment (TME).

Main Results:

  • Adjuvant therapies, particularly AATs targeting VEGF-VEGFR, enhance myeloid cell infiltration, contributing to GBM resistance.
  • Myeloid cells play a critical role in Glioblastoma (GBM) tumor relapse and therapy resistance.
  • Targeting the TME presents a promising strategy to overcome resistance.

Conclusions:

  • Future Glioblastoma (GBM) research should focus on TME-directed therapies combined with standard treatments.
  • Clinical trials investigating novel combination therapies are essential.
  • Development of new GBM models is needed to explore innovative therapeutic approaches.
Keywords:
Glioblastomaantiangiogenic therapybone marrow-derived cellsmyeloid cellsneovascularizationresistancetumor microenvironment

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