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Age-related sarcopenia and its pathophysiological bases.
Sumito Ogawa1, Mitsutaka Yakabe1, Masahiro Akishita1
1Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655 Japan.
Inflammation and Regeneration
|December 21, 2017
Summary
Sarcopenia, the age-related loss of muscle mass and function, is diagnosed using gait speed, grip strength, and muscle mass. Chronic inflammation and lifestyle factors may contribute to sarcopenia progression.
Area of Science:
- Gerontology
- Muscle physiology
- Inflammology
Background:
- Sarcopenia is characterized by age-related decline in skeletal muscle mass and function.
- Established diagnostic criteria include gait speed, grip strength, and skeletal muscle mass.
- The precise mechanisms and pathophysiology of sarcopenia require further elucidation.
Purpose of the Study:
- To explore the potential contribution of chronic inflammatory status to sarcopenia.
- To investigate the role of lifestyle-related factors in the development and progression of sarcopenia in older adults.
Main Methods:
- Review of recent scientific literature on sarcopenia.
- Analysis of studies investigating inflammatory markers in aging populations.
- Examination of epidemiological data on lifestyle factors and muscle health.
Main Results:
- Emerging evidence suggests a link between chronic inflammation and sarcopenia.
- Lifestyle factors, such as physical activity and nutrition, appear to influence sarcopenia.
- These factors may play a significant role in the pathophysiology of age-related muscle loss.
Conclusions:
- Chronic inflammation and lifestyle factors are implicated in sarcopenia.
- Further research is needed to fully understand and target these mechanisms.
- Interventions addressing inflammation and lifestyle may help mitigate sarcopenia.
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