Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.9K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

5.7K
The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
5.7K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

8.2K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.2K
Abnormal Proliferation02:23

Abnormal Proliferation

5.3K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuronal death and accumulation of lipid droplets and glycogen granules within retinal pigment epithelium under the influence of mTOR and autophagy.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same author

Spontaneous whole retinal degeneration in aged Beclin1 heterozygous mice.

Journal of neural transmission (Vienna, Austria : 1996)·2026
Same author

Virtual Human White Matter Dissection: A Stratigraphic Layer-by-Layer Dissection of Human Brain in Photogrammetry.

Operative neurosurgery (Hagerstown, Md.)·2026
Same author

Brain Metastasis From Anal Canal Squamous Cell Carcinoma: A Rare Case Report and Systematic Review.

Clinical colorectal cancer·2026
Same author

Short-Term Effects of Capacitive and Resistive Electric Transfer Therapy and Static Splinting in the Management of Trigger Finger: A Non-Randomized Clinical Study.

Life (Basel, Switzerland)·2026
Same author

Surgical treatment of recurrent glioblastoma: a multicenter perspective from the Italian society of neurosurgery (SINch<sup>®</sup>) and a systematic review.

Neurosurgical review·2026

Related Experiment Video

Updated: Feb 16, 2026

Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress
09:51

Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress

Published on: May 7, 2014

15.9K

mTOR-Dependent Cell Proliferation in the Brain.

Larisa Ryskalin1, Gloria Lazzeri1, Marina Flaibani1

  • 1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126 Pisa, Italy.

Biomed Research International
|December 21, 2017
PubMed
Summary
This summary is machine-generated.

The mammalian Target of Rapamycin (mTOR) pathway regulates cell growth and is crucial in brain development. Its upregulation is linked to aggressive brain tumors like Glioblastoma Multiforme (GBM), contributing to poor outcomes.

More Related Videos

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
10:13

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Published on: August 12, 2014

13.9K
Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research
06:25

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research

Published on: March 29, 2024

1.6K

Related Experiment Videos

Last Updated: Feb 16, 2026

Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress
09:51

Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress

Published on: May 7, 2014

15.9K
Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
10:13

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Published on: August 12, 2014

13.9K
Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research
06:25

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research

Published on: March 29, 2024

1.6K

Area of Science:

  • Molecular Biology
  • Oncology
  • Neuroscience

Background:

  • The mammalian Target of Rapamycin (mTOR) is a kinase complex vital for cell viability and metabolic regulation.
  • mTOR integrates environmental signals to control cell growth, proliferation, autophagy, and protein synthesis.
  • Aberrant mTOR signaling is implicated in diseases including obesity, neurodegeneration, and brain tumors.

Purpose of the Study:

  • To review the role of mTOR signaling in normal brain development.
  • To discuss the pathological implications of mTOR upregulation, particularly in high-grade gliomas.
  • To emphasize mTOR's specific role in Glioblastoma Multiforme (GBM) malignancy.

Main Methods:

  • Literature review of experimental and pathological findings.
  • Analysis of mTOR's function in cellular processes.
  • Examination of mTOR's association with tumor aggressiveness and treatment resistance.

Main Results:

  • mTOR upregulation is associated with aggressive phenotypes in high-grade gliomas.
  • mTOR plays a key role in Glioblastoma Multiforme (GBM) malignancy, promoting proliferation and invasion.
  • mTOR-induced autophagy suppression is a critical factor in GBM progression and chemoresistance.

Conclusions:

  • mTOR signaling is a significant driver of GBM aggressiveness, relapse, and chemoresistance.
  • Targeting mTOR pathways may offer therapeutic strategies for GBM patients.
  • Understanding mTOR's role is crucial for developing effective treatments for this lethal brain tumor.