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Published on: August 4, 2011
Hypertensive retinopathy as the initial presentation of neuroblastoma
Anna Djougarian1, Sylvia Kodsi1
1Northwell Health Department of Ophthalmology, Great Neck, NY, United States.
Purpose:
To describe a case of a patient who presented with hypertensive retinopathy and was found to have neuroblastoma.
Observations:
Neuroblastoma has three main ocular presentations. As a primary disease, it can present with a paraneoplastic syndrome in the form of opsoclonus, or it can present as a Horner's syndrome from its effect on the cervical sympathetic ganglia. Metastatic disease can present as a triad of periorbital edema, ecchymosis and proptosis from orbital bone involvement. Hypertension is a rare systemic presentation of neuroblastoma. We report the case of a two-year-old girl whose initial presentation of neuroblastoma was hypertensive retinopathy.
Conclusions And Importance:
To our knowledge, this is the first reported case of neuroblastoma presenting as hypertensive retinopathy. Our case highlights the importance of a multidisciplinary approach and thorough systemic work up of ocular findings in order to arrive at an appropriate diagnosis.
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