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Updated: Feb 16, 2026

Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
[Advances in the Diagnosis and Therapy of Primary Plasma Cell Leukemia -Review]
Huan Wang1, Jian-Yong Li2, Chao Sun1
1Department of Hematology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, Jiangsu Province, China.
Abstract:
Primary plasma cell leukemia (PPCL) is an uncommon and very aggressive hematological disease, which has different cytogenetic abnormalities, special molecular and biological characteristics, compared with multiple myeloma(MM). The clinical course is unfavorable with short remissions and reduced overall survival(OS). Intensive chemotherapy regimens and bortezomib-based regimens, immunoregulatory drugs(IMiDs) as well as stem cell transplantation may be beneficial to PPCL patients. This review summarizes the recent advances of this malignant disease, including clinical and biochemical characteristics of PPCL, therapy and prognosis of PPCL, new drugs for PPCL and so on.
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