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Updated: Feb 16, 2026
Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
Published on: June 4, 2020
Effect of Serum Immunoglobulins on Routine Coagulation Tests: A Comparison of Coagulation Analyzers using Mechanical
Ginell R Post1, Elizabeth Guillory2, Curtis L Wade2
1Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA gpost@uams.edu.
Background:
We previously showed that the prothrombin time (PT), but not activated partial thromboplastin time (APTT), is correlated with serum immunoglobulin level in patients with plasma cell neoplasms.
Methods:
To determine if the observed effect of serum immunoglobulins on PT was reagent and/or method dependent, PT and APTT were measured in plasma samples obtained from patients referred to the Myeloma Institute using mechanical (STAR Evolution; Diagnostica Stago) and optical clot detection (ACL TOP 500 analyzer; Instrumentation Laboratory) and manufacturer provided reagents.
Results:
A total of 97 patients were included in this study. Twelve patients had abnormal coagulation test results. An isolated prolonged PT was found in 8 patients and an isolated prolonged PTT was detected in 4 patients.
Conclusion:
The PT, but not APTT, was positively correlated with serum paraprotein level and this correlation was observed regardless of the reagents and instrumentation used to assess clot time.
