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Acute Appendicitis and Mean Platelet Volume: A Systemic Review and Meta-analysis

Zhe Fan1, Yingyi Zhang1, Jiyong Pan1

  • 1Department of General Surgery, the Third People's Hospital of Dalian, Dalian Medical University, Dalian, China.

Annals of Clinical and Laboratory Science
|December 22, 2017
PubMed
Abstract

Insights

Mean platelet volume (MPV) is significantly lower in patients with acute appendicitis (AA). This finding supports MPV as a potential biomarker for diagnosing AA, a common surgical condition.

Area of Science:

  • General Surgery
  • Inflammation Markers
  • Hematology

Background:

  • Acute appendicitis (AA) is a prevalent surgical condition with potential severe complications like septicemia.
  • Mean platelet volume (MPV) is a platelet parameter that may indicate inflammatory processes.
  • The relationship between AA and MPV requires further investigation.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between mean platelet volume (MPV) and acute appendicitis (AA).
  • To determine if MPV can serve as a diagnostic biomarker for AA.

Main Methods:

  • Systematic literature search of PubMed and Embase databases (1966-2015).
  • Inclusion of five case-control studies comprising 1416 AA cases and 685 controls.
  • Calculation of weighted mean difference and 95% confidence intervals using Stata 12.0 software.

Main Results:

  • A significant decrease in MPV levels was observed in patients with AA compared to control groups.
  • The weighted mean difference for MPV was -0.64 (95% CI, -0.74 to -0.54; P=0.037).
  • Five case-control studies met the inclusion criteria for the meta-analysis.

Conclusions:

  • Patients diagnosed with acute appendicitis exhibit lower mean platelet volume (MPV) levels.
  • MPV demonstrates potential as a valuable biomarker for the diagnosis of acute appendicitis.
Keywords:
Acute appendicitis (AA)mean platelet volume(MPV)meta-analysis

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