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Updated: Feb 16, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Acute Appendicitis and Mean Platelet Volume: A Systemic Review and Meta-analysis
Zhe Fan1, Yingyi Zhang1, Jiyong Pan1
1Department of General Surgery, the Third People's Hospital of Dalian, Dalian Medical University, Dalian, China.
Background:
Acute appendicitis (AA) is a common condition in general surgery, often with serious consequences such as septicemia and intra-abdominal infection. Mean platelet volume (MPV) - a platelet parameter - could be an index of inflammation. We carried out the present study to perform a meta-analysis of AA and MPV.
Methods:
A systematic search was conducted in databases of PubMed and Embase from 1966 to 2015. Weighted mean difference and 95% confidence interval (CI) were then calculated. Finally, statistical analysis was carried out using Stata 12.0 software.
Results:
Of the 88 selected studies, five case-control studies met the selection criteria. These cases, comprised1416 cases of AA and 685 controls. The results showed a prominent decrease of MPV levels in patients suffering from AA, compared to the control group. (weighted mean difference, -0.64; 95% CI, -0.74 to -0.54; P=0.037).
Conclusions:
AA cases had a lower MPV than the controls, which supports MPV as a potential biomarker of AA.
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