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Heartbeat Complexity Modulation in Bipolar Disorder during Daytime and Nighttime.
Mimma Nardelli1, Antonio Lanata2, Gilles Bertschy3
1Computational Physiology and Biomedical Instruments group, Department of Information Engineering & Bioengineering and Robotics Research Centre E. Piaggio, School of Engineering, University of Pisa, Pisa, Italy. mimma.nardelli@for.unipi.it.
Scientific Reports
|December 22, 2017
Summary
Bipolar disorder is linked to reduced heartbeat complexity, especially during depressive and hypomanic states. This complexity loss is more pronounced during sleep, suggesting autonomic nervous system dysregulation.
Area of Science:
- Cardiology
- Psychiatry
- Biomedical Engineering
Background:
- Bipolar disorder significantly impacts patients' quality of life.
- Autonomic Nervous System (ANS) dysregulation is implicated in mental health conditions.
- Heartbeat complexity analysis offers insights into physiological states.
Purpose of the Study:
- To investigate heartbeat complexity modulation in bipolar disorder patients across different mood states.
- To compare complexity dynamics between patients and healthy controls.
- To explore diurnal and nocturnal variations in heartbeat complexity.
Main Methods:
- Multiscale entropy analysis applied to R-R interval series from electrocardiographic (ECG) signals.
- Monitoring using textile-based sensorized t-shirts for diurnal and nocturnal recordings.
- Analysis of data from 8 bipolar disorder patients (across depression, hypomania, euthymia) and 11 healthy controls.
Main Results:
- A significant loss of heartbeat complexity was observed in bipolar patients during depressive and hypomanic states compared to euthymic states and healthy controls.
- Complexity modulation was more pronounced during nocturnal recordings, indicating enhanced sleep-related dysregulation.
- Heartbeat complexity dynamics differed significantly between healthy individuals and those with bipolar disorder.
Conclusions:
- Bipolar disorder is associated with reduced heartbeat complexity, reflecting altered Autonomic Nervous System (ANS) activity.
- Sleep-related ANS dysregulation appears heightened in bipolar disorder.
- Heartbeat complex dynamics may serve as a potential biomarker for mental health conditions.
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