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Related Concept Videos

Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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Related Experiment Video

Updated: Feb 16, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
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Multiple Synchronous Primary Carcinoma of the Colon.

S R Chowdhury1

  • 1Hawera Hospital, Hawera, Taranaki, New Zealand.

The Australian and New Zealand Journal of Surgery
|December 22, 2017
PubMed
Summary

This case study describes multiple primary colon cancers occurring simultaneously with extensive diverticulitis. The review examines the incidence and potential causes of this rare association in colorectal cancer.

Area of Science:

  • Gastroenterology
  • Oncology
  • Colorectal Surgery

Background:

  • Colorectal cancer (CRC) is a significant health concern.
  • Diverticulitis is a common condition affecting the colon.
  • Synchronous primary tumors are rare but clinically important.

Purpose of the Study:

  • To present a case of multiple synchronous primary colon carcinomas.
  • To highlight the association with extensive diverticulitis.
  • To review the incidence and etiology of this condition.

Main Methods:

  • Case report presentation.
  • Literature review on synchronous primary colorectal cancers.
  • Literature review on diverticulitis and its association with malignancy.

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Main Results:

  • A case of multiple synchronous primary colon carcinomas was identified.
  • The patient presented with extensive diverticulitis of the descending and pelvic colon.
  • Review of existing literature on the incidence and etiological factors.

Conclusions:

  • The coexistence of multiple synchronous primary colon cancers and extensive diverticulitis is rare.
  • Further research is needed to elucidate the potential etiological links.
  • Awareness of this association is crucial for accurate diagnosis and treatment planning.