Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

1.4K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.4K
Metal-Ligand Bonds02:51

Metal-Ligand Bonds

24.6K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
24.6K
Formation of Complex Ions03:45

Formation of Complex Ions

26.3K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
26.3K
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

872
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
872
Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

2.4K
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
2.4K
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

3.5K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Easily Accessible and Up-Scalable Aliphatic Bis-Formamides with Afterglow Luminescence: Photoluminescence Properties and Applications.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Experimentally Validated Quantum-Secure Federated Learning over a Multi-user Quantum Network.

Research (Washington, D.C.)·2026
Same author

Design and application of amino acid-derived aromatic scaffolds in supramolecular covalent and non-covalent systems.

Chemical communications (Cambridge, England)·2026
Same author

Dynamic Control of Nucleic Acids Self-Assembly and Expression Using Photoswitches.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Molecular Recognition-Driven Reaction-Based Sensing of Catecholamines in a Lipid Nanoreactor.

Journal of the American Chemical Society·2026
Same author

Ligand Side-Chains Control the Formation of an M<sub>8</sub>L<sub>4</sub> Molecular Barrel: Unveiling Selective Encapsulation and Sequential Separation Properties.

Inorganic chemistry·2026

Related Experiment Video

Updated: Feb 16, 2026

Synthesis of a Water-soluble Metal&#8211;Organic Complex Array
06:40

Synthesis of a Water-soluble Metal–Organic Complex Array

Published on: October 8, 2016

12.0K

Switching Multivalent DNA Complexation using Metal-Controlled Cationic Supramolecular Self-Assemblies.

Wojciech Drożdż1,2, Yannick Bessin3, Virginie Gervais4

  • 1Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614, Poznań, Poland.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|December 22, 2017
PubMed
Summary

Coordination chemistry enables inactive ligands to self-assemble into DNA-complexing clusters. Metal coordination and scavenging allow for controlled DNA complexation and decomplexation, demonstrating a novel approach to DNA binding systems.

Keywords:
DNA recognitioncoordination chemistrymultivalencyself-assemblyswitches

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

8.0K
Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

19.3K

Related Experiment Videos

Last Updated: Feb 16, 2026

Synthesis of a Water-soluble Metal&#8211;Organic Complex Array
06:40

Synthesis of a Water-soluble Metal–Organic Complex Array

Published on: October 8, 2016

12.0K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

8.0K
Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

19.3K

Area of Science:

  • Coordination Chemistry
  • Supramolecular Chemistry
  • Biotechnology

Background:

  • Ligands often require specific activation or modification for targeted molecular interactions.
  • Controlling the assembly and disassembly of molecular structures is crucial for advanced applications.

Purpose of the Study:

  • To demonstrate that coordination chemistry can drive the in situ self-assembly of an inactive ligand.
  • To create a multivalent cluster capable of effectively complexing DNA.
  • To show that metal coordination and scavenging can control DNA complexation.

Main Methods:

  • Utilizing coordination chemistry principles for ligand self-assembly.
  • Employing metal coordination and scavenging techniques.
  • Investigating the complexation and decomplexation dynamics with DNA.

Main Results:

  • An inactive ligand was successfully self-assembled into a multivalent cluster via coordination chemistry.
  • The system demonstrated effective complexation with DNA.
  • Metal coordination and scavenging were shown to reversibly switch the system's multivalency.

Conclusions:

  • Coordination chemistry is a viable strategy for generating functional supramolecular assemblies from inactive precursors.
  • The developed system offers controlled DNA complexation and decomplexation, opening avenues for DNA-based technologies.