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Updated: Feb 16, 2026

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice

Published on: October 17, 2018

Zika Virus Vaccine Development.

Kaitlyn M Morabito¹, Barney S Graham¹

¹Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

The Journal of Infectious Diseases

|December 22, 2017

Summary

This summary is machine-generated.

Rapid Zika virus vaccine development, driven by prior flavivirus knowledge, has yielded multiple clinical candidates. This swift response highlights the capacity for future pandemic preparedness with adequate funding and cooperation.

Keywords:

DNA Zika virus chimeric live-attenuated mRNA vaccine development whole-inactivated

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Last Updated: Feb 16, 2026

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice

Published on: October 17, 2018

Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons

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Published on: August 23, 2016

Quantification of Antibody-dependent Enhancement of the Zika Virus in Primary Human Cells

Quantification of Antibody-dependent Enhancement of the Zika Virus in Primary Human Cells

Published on: January 18, 2019

Area of Science:

Virology
Immunology
Vaccinology

Background:

Zika virus emergence in Brazil linked to microcephaly and Guillain-Barré syndrome.
Prior flavivirus research provided foundational knowledge for vaccine strategies.

Purpose of the Study:

To accelerate the development of Zika virus vaccines.
To evaluate multiple vaccine platforms for efficacy and safety.

Main Methods:

Leveraging existing flavivirus vaccine knowledge, particle structure, and antigenic targets (E dimers).
Developing diverse vaccine candidates including nucleic acid, inactivated virus, live-attenuated/chimeric virus, and protein/virus-like particle platforms.

Main Results:

Multiple Zika vaccine candidates rapidly advanced to clinical trials.
Seven products currently in clinical trials, with over 40 in preclinical development.
Unprecedented speed in vaccine development achieved within one year of WHO Public Health Emergency declaration.

Conclusions:

Prior scientific knowledge is crucial for rapid pandemic response.
Sufficient funding and interagency cooperation are key to effective public health preparedness.
The Zika vaccine development serves as a model for future emerging infectious disease threats.