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Published on: June 30, 2023
Pre-administration of rats with Helicobacter pylori γ-glutamyl-transpeptidase alleviates osteoarthritis
Xiaofeng Yang1, Zhengxiang Lv2, Guohua Xie2
1Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210023, People's Republic of China.
Objective:
To determine the efficacy of Helicobacter pylori γ-glutamyl-transpeptidase (GGT) in osteoarthritis (OA) therapy.
Results:
Oral administration of rats with rGGT alleviated joint pain in the acute phase of iodoacetate (IA)-induced OA. The CXCL1/IL-6 in blood and in articular tissue as well as circulating granulocytes in the recipients of GGT, were reduced. This might be associated with the expansion of regulatory T cells in the inguinal lymph nodes and increased articular IL-10.
Conclusion:
We provide preclinical evidence that H. pylori GGT may represent a promising candidate for OA therapy.
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