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[Development and application of component-based Chinese medicine theory]
Jun-Hua Zhang1,2, Guan-Wei Fan1,2, Han Zhang1,2
1Institute of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Summary
Component-based Chinese medicine (CCM) advances traditional therapies by shifting from herbal pieces to active components. This innovation bridges traditional Chinese medicine (TCM) with modern science, improving drug quality and developing new treatments.
Area of Science:
- Pharmacology and Pharmaceutical Sciences
- Integrative and Complementary Medicine
- Traditional Chinese Medicine (TCM) Research
Background:
- Traditional Chinese medicine (TCM) prescriptions, while effective for complex diseases, lack robust scientific validation of active substances and mechanisms.
- The reliance on empirical prescription methods in TCM hinders understanding of efficacy regularities and quality control of medicinal products.
- Component-based Chinese medicine (CCM) represents a modernization effort, transitioning from traditional herbal piece compatibility to component-level compatibility.
Purpose of the Study:
- To explore the research progress, core concepts, and technological advancements in Component-based Chinese medicine (CCM).
- To elucidate the scientific underpinnings of TCM prescription compatibility and foster the development of innovative Chinese drugs.
- To establish CCM as a bridge between traditional Chinese medicine and modern scientific methodologies.
Main Methods:
- Theoretical innovation and technological development focused on the "two relatively clear" principles (identifying active components and their effects).
- Analysis of research progress and application expansion of CCM over the past decade.
- Review of CCM's role in theory research, drug development, and pharmaceutical technology upgrading.
Main Results:
- CCM has evolved significantly, improving theories and methods for efficacy-oriented compatibility.
- CCM facilitates the development of new drugs and enhances the quality of existing Chinese medicinal products.
- The CCM approach provides a systematic framework for TCM innovation and development.
Conclusions:
- Component-based Chinese medicine (CCM) is a crucial innovation for the modernization of traditional Chinese medicine (TCM).
- CCM enhances scientific understanding, drug quality, and the development of novel therapeutics.
- CCM serves as a vital link between traditional knowledge and contemporary scientific research and pharmaceutical development.
