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Light-Responsive Biodegradable Nanorattles for Cancer Theranostics
Chunxiao Li1,2, Yifan Zhang2, Zhiming Li1
1Department of Dermatology and Venereology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, P. R. China.
Advanced Materials (Deerfield Beach, Fla.)
|December 23, 2017
Summary
This study introduces a novel nanorattle for cancer nanotheranostics. The gold nanorod-based system enhances dual-modality imaging and photothermal therapy for melanoma.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Cancer nanotheranostics integrate diagnostics and therapeutics for improved cancer management.
- Developing advanced nanoscale agents is crucial for effective cancer treatment strategies.
Purpose of the Study:
- To design and prepare a light-responsive, biodegradable nanorattle for dual-modality imaging and photothermal therapy of melanoma.
- To investigate the potential of gold nanorod-silica-perfluoropentane nanorattles (GNR@SiO2-PFP) for enhanced cancer treatment.
Main Methods:
- Fabrication of GNR@SiO2-PFP nanorattles with a mesoporous silica shell and perfluoropentane (PFP) core.
- Utilizing 808 nm laser irradiation to induce PFP liquid-gas phase transition for nanobubble generation.
- Evaluating ultrasound (US) and photoacoustic (PA) imaging capabilities, biocompatibility, biodegradability, and photothermal therapy efficacy in melanoma models.
Main Results:
- The GNR@SiO2-PFP nanorattles demonstrated flexible morphology, excellent biodegradability, and efficient PFP loading.
- Laser irradiation triggered nanobubble formation and coalescence, enhancing intratumoral permeation and US imaging signals.
- The nanotheranostic platform showed good US/PA imaging contrast, excellent biocompatibility, and significant photothermal therapy efficiency.
Conclusions:
- The developed GNR@SiO2-PFP nanorattles show significant promise as a versatile platform for cancer nanotheranostics.
- This system offers enhanced dual-modality imaging and targeted photothermal therapy for melanoma, paving the way for advanced cancer management.
