Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

2.6K
Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
2.6K
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

1.6K
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
1.6K
Titrimetric Methods: Types and Commonly Used Strategies01:08

Titrimetric Methods: Types and Commonly Used Strategies

2.6K
In chemistry, titrimetric methods are broadly classified into three types: volumetric, gravimetric, and coulometric. Volumetric titrations involve measuring the volume of a titrant of known concentration that is required to react completely with an analyte. In gravimetric titrations, the standard solution reacts with the analyte to form an insoluble precipitate, which is filtered, dried, and weighed. In coulometric titrations, current is applied to an electrochemical reaction until the reaction...
2.6K
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

1.9K
Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
1.9K
Ion-Exchange Chromatography01:09

Ion-Exchange Chromatography

2.3K
Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
2.3K
Classification of Titrimetric Analysis Based on Reaction Types01:01

Classification of Titrimetric Analysis Based on Reaction Types

1.9K
Titrimetric analysis in solution chemistry involves measuring the volume of solutions and is often called volumetric analysis. The standard solution of known concentration in the burette is called the titrant, whereas the solution of unknown concentration in the flask is called the analyte, or titrand. Titrimetric analyses can be classified into four types based on the reactions between the titrant and analyte.
Titrations between an acid and a base lead to neutralization reactions that form...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrafast Self-Assembly of Zeolitic Imidazolate Framework-8 Enables Antibody Orientation for Ultrasensitive Lateral Flow Immunoassays.

ACS nano·2026
Same author

Programmable DNA hydrogels for dual-mode PD-L1 suppression via polyvalent LYTAC mimics and transcriptional silencing.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

On-demand formation of ultrathin liquid metal hydrogel tattoos for conformal and low-impedance bioelectronics.

Science advances·2026
Same author

Liquid Metal-Enabled Soft Bioelectronics for Human Health Monitoring.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Remote-Controlled Microfluidic Platform for Real-Time Detection of Multiple Mycotoxins on Chip.

Foods (Basel, Switzerland)·2026
Same author

Side-Port Puncture Needle-Assisted, Multistep Vacuum-Driven Microfluidic Chip for Multiplexed Molecular Analysis.

Analytical chemistry·2026

Related Experiment Video

Updated: Feb 16, 2026

TD-DFT Guided Advanced E-Eye Sensing Technique for On-site Quantification of Fe, Cr, F, and As in the Environmental, Biological, and Food Samples
09:51

TD-DFT Guided Advanced E-Eye Sensing Technique for On-site Quantification of Fe, Cr, F, and As in the Environmental, Biological, and Food Samples

Published on: September 19, 2025

522

Versatile T1-Based Chemical Analysis Platform Using Fe3+/Fe2+ Interconversion.

Yiping Chen1, Binfeng Yin1, Mingling Dong1

  • 1Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nano-safety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology , No. 11 Beiyitiao, Zhongguancun, Beijing, 100190, People's Republic of China.

Analytical Chemistry
|December 23, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a novel analytical platform using longitudinal relaxation time (T1) changes for versatile biomedical analysis. The T1-based assay avoids magnetic nanoparticles, offering improved stability and sensitivity for various applications.

More Related Videos

Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy
07:49

Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy

Published on: February 20, 2020

10.0K
Thermochemical Studies of NiII and ZnII Ternary Complexes Using Ion Mobility-Mass Spectrometry
16:11

Thermochemical Studies of NiII and ZnII Ternary Complexes Using Ion Mobility-Mass Spectrometry

Published on: June 8, 2022

2.8K

Related Experiment Videos

Last Updated: Feb 16, 2026

TD-DFT Guided Advanced E-Eye Sensing Technique for On-site Quantification of Fe, Cr, F, and As in the Environmental, Biological, and Food Samples
09:51

TD-DFT Guided Advanced E-Eye Sensing Technique for On-site Quantification of Fe, Cr, F, and As in the Environmental, Biological, and Food Samples

Published on: September 19, 2025

522
Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy
07:49

Characterizing Lewis Pairs Using Titration Coupled with In Situ Infrared Spectroscopy

Published on: February 20, 2020

10.0K
Thermochemical Studies of NiII and ZnII Ternary Complexes Using Ion Mobility-Mass Spectrometry
16:11

Thermochemical Studies of NiII and ZnII Ternary Complexes Using Ion Mobility-Mass Spectrometry

Published on: June 8, 2022

2.8K

Area of Science:

  • Biomedical analysis
  • Analytical chemistry
  • Magnetic resonance imaging

Background:

  • Conventional magnetic biosensors face challenges with MNP stability, including nonspecific adsorption and aggregation.
  • Existing methods may lack the versatility for diverse analytical applications.

Purpose of the Study:

  • To develop a versatile analytical platform for multiple analyte detection using T1 relaxation time.
  • To overcome limitations of conventional magnetic biosensors by eliminating the need for magnetic nanoparticles.

Main Methods:

  • Utilizing the distinct T1 relaxation times of Fe3+ and Fe2+ in aqueous solutions.
  • Leveraging redox reactions for Fe3+/Fe2+ interconversion to induce measurable T1 changes.
  • Implementing both one-step mixing and multiple-washing immunoassay formats.

Main Results:

  • Demonstrated a generally applicable T1-based assay free of magnetic nanoparticles (MNPs).
  • Achieved improved stability compared to conventional magnetic sensors susceptible to MNP issues.
  • Showcased versatility through successful one-step and multiple-washing assay implementations.

Conclusions:

  • The T1-based assay offers a stable, sensitive, and versatile platform for biomedical analysis.
  • This method provides a convenient alternative to traditional magnetic biosensors.
  • The platform holds promise for a wide range of diagnostic and analytical applications.