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eHistology image and annotation data from the Kaufman Atlas of Mouse Development
Richard A Baldock1, Chris Armit1
1MRC Human Genetics Unit, Institute of Genomic and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK.
Gigascience
|December 23, 2017
Summary
This study digitizes classic mouse embryo anatomy images, preserving developmental knowledge. The high-resolution dataset enhances research and teaching in mammalian development.
Area of Science:
- Developmental biology
- Histology
- Bioinformatics
Background:
- The "Atlas of Mouse Development" by Kaufman is a foundational resource for mouse embryo anatomy.
- Existing histological images lack high-resolution digital formats and modern ontological assignments.
Purpose of the Study:
- To create a high-resolution digital version of the classic mouse embryo atlas.
- To augment anatomical annotations with standardized ontologies.
- To make the data accessible for research and education.
Main Methods:
- Redigitizing original H&E-stained mouse embryo sections at high resolution.
- Digitally transferring hand-drawn annotations from the original atlas.
- Assigning EMAPA (Embryonic Mouse Anatomy) ontological terms to annotations.
- Developing an online viewer (eHistology) and data archive for public access.
Main Results:
- A comprehensive, high-resolution digital dataset of mouse embryo histology.
- Digitally preserved and augmented anatomical annotations linked to EMAPA.
- Freely accessible data via the eHistology online viewer and DataShare archive.
Conclusions:
- The digitized atlas preserves and enhances the original anatomical knowledge.
- This resource serves as a core dataset for community annotation, teaching, and analysis.
- Provides high-quality histological images for manual and automated analysis in mammalian development research.
