Related Experiment Video

Updated: Feb 16, 2026

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
06:29

Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 1, 2011

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The role of IL-1 in gout: from bench to bedside

Alexander So1, Alexandre Dumusc1, Sonia Nasi1

  • 1Service de Rhumatologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Rheumatology (Oxford, England)
|December 23, 2017
PubMed

The translation of our knowledge of the biology of MSU crystal-induced IL-1 secretion gives rise to new targets and therapeutic strategies in the treatment of acute gout. The NACHT, LRR and PYD domains-containing protein 3 inflammasome is key to this, and is the subject of intense research. Novel pathways that modulate inflammasome activation, reactive oxygen species generation and extracellular processing of IL-1 have been described and show promise in in vitro and animal studies. Meanwhile, blocking IL-1 by various IL-1 inhibitors has shown the validity of this concept. Patients with acute gout treated with these inhibitors showed positive clinical and biological responses. More work needs to be performed to assess the risk/benefit profile of anti-IL-1 therapies as well as to identify those who will benefit the most from this novel approach to the treatment of gout.

Keywords:
IL-1anti-cytokine therapygoutinflammasomeinflammation

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