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Related Experiment Videos

Choreoathetosis induced by cyproheptadine.

M R Samie1, A K Ashton

  • 1Department of Neurology, State University of New York, Buffalo.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 1, 1989
PubMed
Summary

Cyproheptadine overdose can cause involuntary movement disorders like choreoathetosis, a rare side effect. Physostigmine effectively treated the associated delirium in a teenage patient.

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Area of Science:

  • Pharmacology
  • Neurology
  • Toxicology

Background:

  • Cyproheptadine is an antihistamine with antiserotoninergic and anticholinergic properties.
  • It is generally considered safe with diverse clinical applications.
  • Serious adverse neurologic sequelae are uncommon with cyproheptadine use.

Observation:

  • A case report details a 17-year-old presenting with overdose symptoms.
  • The patient exhibited involuntary movement disorder, specifically choreoathetosis.
  • This hyperkinetic movement is a rare reported adverse effect of cyproheptadine.

Findings:

  • The choreoathetosis in this case is hypothesized to stem from cyproheptadine's anticholinergic effects.
  • The involuntary movements resolved spontaneously over time.
  • Associated delirium was successfully treated with physostigmine administration.

Implications:

  • This case highlights a rare neurological complication of cyproheptadine intoxication.
  • It underscores the potential for anticholinergic properties to induce movement disorders.
  • Physostigmine may be a viable treatment for cyproheptadine-induced delirium.

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