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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
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Overwork accelerates thrombotic reaction: implications for the pathogenesis of Karoshi
Kazunori Otsui1, Junichiro Yamamoto2, Nobutaka Inoue3
1Department of General Internal Medicine, Kobe University Hospital, Kobe, Japan.
Journal of Thrombosis and Thrombolysis
|December 24, 2017
Summary
Work-related stress significantly impacts blood clotting and clot breakdown. Occupational stress accelerates thrombotic reactions, potentially explaining cardiovascular disease development and stroke.
Area of Science:
- Cardiovascular Science
- Occupational Health
- Hemostasis Research
Background:
- Work-related stress is linked to cardiovascular diseases (CVDs) and stroke.
- The precise mechanisms by which occupational stress affects CVDs are not fully understood.
Purpose of the Study:
- To investigate the impact of work-related stress on thrombotic and thrombolytic reactions.
- To evaluate the utility of the global thrombosis test (GTT) in assessing fatigue.
Main Methods:
- Assessed thrombotic and thrombolytic reactions using the global thrombosis test (GTT) in 46 healthy medical residents.
- Collected blood samples during off-duty and on-duty (after night shifts) periods.
- Measured occlusion time (OT) for thrombosis and lysis time (LT) for thrombolysis.
Main Results:
- On-duty OT was significantly shorter than off-duty OT, indicating accelerated thrombosis.
- LT was significantly prolonged during overwork compared to off-duty, suggesting impaired thrombolysis.
- Sleep duration was significantly reduced during night duty.
Conclusions:
- Overwork accelerates thrombotic reactions, potentially contributing to the pathogenesis of overwork-related CVDs.
- The GTT is effective in evaluating fatigue levels and their impact on hemostasis.
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