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The altered platelet mineral ratios in pregnancy complicated with intrauterine growth restriction

Barbara Poniedziałek1, Joanna Nowaczyk2, Mariola Ropacka-Lesiak2

  • 1Department of Environmental Medicine, Faculty of Health Sciences, Poznan University of Medical Sciences, Poznan, Poland.

Reproductive Toxicology (Elmsford, N.Y.)
|December 27, 2017
PubMed

Insights

Maternal platelets in intrauterine growth restriction (IUGR) show altered trace element levels. Specifically, calcium, magnesium, and zinc were lower, while certain ratios were higher in IUGR pregnancies, impacting platelet function.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Biochemistry

Background:

  • Maternal platelet function is altered in intrauterine growth restriction (IUGR).
  • The intraplatelet concentration of trace elements, which influence platelet activity, is unknown in IUGR pregnancies.

Purpose of the Study:

  • To assess the intraplatelet status of calcium (Ca), copper (Cu), magnesium (Mg), sodium (Na), potassium (K), phosphorus (P), and zinc (Zn) in IUGR pregnancies.
  • To evaluate specific mineral ratios (Ca/P, Ca/Mg, Na/K, Cu/Zn) in IUGR pregnancies compared to controls.

Main Methods:

  • A comparative study involving pregnant women with IUGR (n=35), uncomplicated pregnancies (n=25), and non-pregnant females (n=25).
  • Analysis of intraplatelet mineral content (Ca, Cu, Mg, Na, K, P, Zn) and their ratios using atomic absorption spectrophotometry or similar techniques.

Main Results:

  • The IUGR group exhibited significantly lower intraplatelet Ca, Mg, Zn, and Ca/P ratio (<1.0).
  • Elevated Ca/Mg and Cu/Zn ratios were observed in the IUGR group.
  • Non-pregnant women and uncomplicated pregnancy groups showed comparable mineral profiles, except for lower P content and Ca/Mg ratio in non-pregnant individuals.
  • Intraplatelet Na, K, and Na/K ratio did not differ significantly across the groups.

Conclusions:

  • Maternal intraplatelet mineral status, particularly Ca, Mg, and Zn, is altered in pregnancies complicated by IUGR.
  • These mineral imbalances may contribute to the altered platelet function observed in IUGR.
  • Further research is warranted to elucidate the precise role of these minerals in IUGR pathophysiology.

Keywords:
Intrauterine growth restrictionMacroelementsMicronutrientsMineral ratiosPlatelets

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