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Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
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Pazopanib for Metastatic Renal Cell Carcinoma: A Registry-based Analysis of 426 Patients

Alexandr Poprach1,2, Ondrej Fiala3,4, Renata Chloupkova5

  • 1Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Anticancer Research
|December 27, 2017
PubMed
Abstract

Insights

Pazopanib effectively treats metastatic renal cell carcinoma (mRCC) in the first-line setting. This study confirms its safety and efficacy, with median overall survival of 33.2 months.

Area of Science:

  • Oncology
  • Clinical Pharmacology

Background:

  • Pazopanib is an approved first-line treatment for metastatic renal cell carcinoma (mRCC).
  • Real-world data on pazopanib's effectiveness and safety in mRCC patients are crucial.

Purpose of the Study:

  • To evaluate the efficacy and safety of pazopanib as a first-line therapy for mRCC.
  • To analyze patient outcomes and toxicity in a real-world setting.

Main Methods:

  • Retrospective analysis of 426 mRCC patients treated with first-line pazopanib.
  • Data sourced from the Renal Cell Carcinoma Information system registry.
  • Analysis included baseline parameters, treatment, outcomes, and toxicity.

Main Results:

  • Median progression-free survival (PFS) was 12.9 months and median overall survival (OS) was 33.2 months.
  • Overall response rate (ORR) was 25.1% and disease control rate (DCR) was 57.4%.
  • Treatment discontinuation due to adverse events occurred in 12.1% of patients.

Conclusions:

  • Pazopanib demonstrates efficacy and safety as a first-line treatment for mRCC.
  • Prognostic models (IMDC, MSKCC) are valid predictors of outcomes.
  • Nephrectomy is associated with improved survival in mRCC patients.
Keywords:
Renal cell carcinomacancer registrypazopanibresponsesurvival

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