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Updated: Feb 16, 2026

Perspectives on Neuroscience
Published on: July 31, 2007
GABA-containing liposomes: neuroscience applications and translational perspectives for targeting neurological
Marco Antônio Peliky Fontes1, Gisele Cristiane Vaz1, Thais Zielke Dias Cardoso1
1Department of Physiology & Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Abstract:
There are multiple challenges for neuropharmacology in the future. Undoubtedly, one of the greatest challenges is the development of strategies for pharmacological targeting of specific brain regions for treatment of diseases. GABA is the main inhibitory neurotransmitter in the central nervous system, and dysfunction of GABAergic mechanisms is associated with different neurological conditions. Liposomes are lipid vesicles that are able to encapsulate chemical compounds and are used for chronic drug delivery. This short review reports our experience with the development of liposomes for encapsulation and chronic delivery of GABA to sites within the brain. Directions for future research regarding the efficacy and practical use of GABA-containing liposomes for extended periods of time as well as understanding and targeting neurological conditions are discussed.
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