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Knobby Eye Syndrome.

Joseph L Demer1

  • 1a Stein Eye Institute and Department of Neurology, Neuroscience Interdepartmental Program, and Bioengineering Interdepartmental Program , University of California , Los Angeles , USA.

Strabismus
|December 28, 2017
PubMed
Summary
This summary is machine-generated.

Non-spherical staphylomata are common in strabismic high myopia, potentially affecting eye muscle function. Magnetic resonance imaging (MRI) reveals these common "knobby eye" conditions in patients with strabismus.

Keywords:
Magnetic resonance imagingmyopiastaphylomastrabismus

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • The traditional assumption of a spherical globe in ophthalmology is challenged by findings in high myopia.
  • Strabismus is frequently associated with anatomical variations in the eye globe.

Purpose of the Study:

  • To investigate the prevalence and characteristics of non-spherical staphylomata in strabismic patients using magnetic resonance imaging (MRI).
  • To compare ocular morphology and muscle path deviations between highly myopic subjects with strabismus and normal controls.

Main Methods:

  • High-resolution, surface coil MRI was performed on 21 highly myopic subjects (36 eyes) and 17 normal controls (33 eyes).
  • Analysis included axial length, eye shape aspect ratio, and deflection of horizontal rectus muscle paths.

Main Results:

  • The majority of highly myopic subjects (19 out of 21) had strabismus.
  • Non-spherical staphylomata (posterior and/or equatorial) were frequently observed in myopic eyes, unlike the generally spherical globes in controls.
  • Globe aspect ratios were significantly greater in myopes, and irregular staphylomata were associated with older age.

Conclusions:

  • Irregular equatorial or posterior staphylomata are common in strabismic, highly myopic individuals.
  • These staphylomata may mechanically interact with eye muscles, potentially altering muscle tension during eye movements.
  • MRI imaging offers valuable clinical insights into this condition, termed 'knobby eye syndrome'.