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A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
Published on: April 19, 2019
Exercise through a cardiac rehabilitation program attenuates oxidative stress in patients submitted to coronary
José Francisco Taty Zau1,2, Rodrigo Costa Zeferino3, Nádia Sandrine Mota3
1a Cardiology Department , University Hospital Clementino Fraga Filho , Rio de Janeiro , Brazil.
Insights
Cardiac rehabilitation programs effectively reduce oxidative stress in patients with coronary artery disease after bypass surgery. Regular exercise helps control biomarkers associated with cardiovascular disease progression.
Area of Science:
- Cardiology
- Biochemistry
- Exercise Physiology
Background:
- Cardiovascular disease (CVD) is a leading global cause of death.
- Oxidative stress plays a key role in CVD pathogenesis.
- Cardiac rehabilitation (CR) may mitigate cardiovascular events by reducing oxidative stress.
Purpose of the Study:
- To assess the impact of a CR program on systemic oxidative stress in patients with coronary artery disease (CAD) post-coronary artery bypass grafting (CABG).
Main Methods:
- Studied 40 patients with chronic stable CAD undergoing CABG who participated in a CR program.
- Monitored key oxidative stress biomarkers in blood samples at various time points during CR.
Main Results:
- Observed a significant, progressive reduction in thiobarbituric acid reactive substances (TBARS) and protein carbonyls.
- Noted initial increases followed by decreases in superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities.
- Documented a progressive rise in uric acid and a late increase in ferric reducing antioxidant power (FRAP).
Conclusions:
- CR programs, incorporating regular exercise, demonstrate the ability to attenuate systemic oxidative stress.
- These findings support CR as a strategy to manage oxidative stress in CAD patients post-CABG.
Background:
Cardiovascular disease is the main cause of morbidity and mortality in the world and oxidative stress has been implicated in the pathogenesis. Cardiac rehabilitation in patients with coronary artery disease submitted to coronary artery bypass grafting may prevent cardiovascular events probably through the attenuation of oxidative stress. The aim of this study was to evaluate the benefits of a cardiac rehabilitation program in the control of the systemic oxidative stress.
Methods:
The studied population consisted of 40 patients, with chronic stable coronary artery disease submitted to coronary artery bypass grafting, who attended a cardiac rehabilitation program. Biomarkers of oxidative stress were evaluated in the blood of these patients at different moments.
Results:
After the onset of cardiac rehabilitation, there was a significant and progressive decrease in thiobarbituric acid reactive substances levels and protein carbonyls, an initial increase and subsequent decrease in superoxide dismutase, catalase and glutathione peroxidase activities. Also, a progressive increase of uric acid, while ferric reducing antioxidant power levels increased only at the end of the cardiac rehabilitation and a tendency to increase of glutathione contents.
Conclusions:
The results suggest that regular exercise through a cardiac rehabilitation program can attenuate oxidative stress in chronic coronary artery disease patients submitted to coronary artery bypass grafting.
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