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Automated blood glucose control in type 1 diabetes: A review of progress and challenges
Arthur Bertachi1, Charrise M Ramkissoon2, Jorge Bondia3
1Institute of Informatics and Applications, University of Girona, Campus de Montilivi, s/n, Edifici P4, 17071 Girona, Spain; Federal University of Technology - Paraná (UTFPR), Guarapuava, Avenida Professora Laura Pacheco Bastos 800, 85053-525 Guarapuava, Paraná, Brazil.
Abstract:
Since the 2000s, research teams worldwide have been working to develop closed-loop (CL) systems able to automatically control blood glucose (BG) levels in patients with type 1 diabetes. This emerging technology is known as artificial pancreas (AP), and its first commercial version just arrived in the market. The main objective of this paper is to present an extensive review of the clinical trials conducted since 2011, which tested various implementations of the AP for different durations under varying conditions. A comprehensive table that contains key information from the selected publications is provided, and the main challenges in AP development and the mitigation strategies used are discussed. The development timelines for different AP systems are also included, highlighting the main evolutions over the clinical trials for each system.
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